| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 02/10/25 18.45 | Rayo Vallecano | KF Shkendija | -:- |
| 02/10/25 18.45 | Jagiellonia Bialystok | Hamrun Spartans | -:- |
| 02/10/25 18.45 | Lech Poznan | SK Rapid Vienna | -:- |
| 02/10/25 18.45 | Omonia Nicosia | FSV Magonza 05 | -:- |
| 02/10/25 18.45 | FC Noah | HNK Rijeka | -:- |
| 02/10/25 18.45 | FC Lausanne-Sport | Breidablik Kopavogur | -:- |
| 02/10/25 18.45 | HŠK Zrinjski Mostar | Lincoln Red Imps FC | -:- |
| 02/10/25 18.45 | Kuopion PS | KF Drita Gjilan | -:- |
| 02/10/25 18.45 | Dynamo Kiev | Crystal Palace | -:- |
| 02/10/25 21.00 | NK Celje | AEK Atene | -:- |
| 02/10/25 21.00 | FC Shelbourne | BK Häcken | -:- |
| 02/10/25 21.00 | AEK Larnaka | AZ Alkmaar | -:- |
| 02/10/25 21.00 | FC Aberdeen | Shakhtar Donezk | -:- |
| 02/10/25 21.00 | KS Rakow Czestochowa | Universitatea Craiova | -:- |
| 02/10/25 21.00 | Sparta Praga | Shamrock Rovers | -:- |
| 02/10/25 21.00 | SK Slovan Bratislava | Racing Club Strasburgo | -:- |
| 02/10/25 21.00 | Legia Varsavia | Samsunspor | -:- |
| 02/10/25 21.00 | Fiorentina | Sigma Olomouc | -:- |